Biology & Ecology
Biology
Gram Statusgram-positive
Oxygen Toleranceobligate anaerobe
Morphologyunknown
Ecology
Primary Nichesgut
Reservoirhuman
Clinical Profile
Pathobiont
yes
no
context dependent
unknown
Clinical Rolescommensal
Typical Specimenstool
Risk Contextsmelanoma patients receiving immune checkpoint inhibitor therapy (ICB)
Clinical Associations:
E2
E3 — Strong human clinical evidence
E2 — Moderate human evidence
E1 — Limited / preliminary
Roseburia intestinalis was among 2 commensal species significantly enriched in pre-treatment stool of metastatic melanoma anti-PD-1 non-responders (n=26) versus responders (n=16) by integrated 16S rRNA, shotgun metagenomic, and qPCR analysis (P<0.05, permutation test); higher abundance was part of a 'non-beneficial' OTU signature inversely correlated with anti-PD-1 response (RECIST % change).
PMID:
29302014
Last reviewed: 2026-04-03
Evidence Timeline
Related Taxa
Shared Niche = same body site
Shared Risk = same vulnerable population
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