Enterobacteriaceae
Bacteria › Pseudomonadota › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae
MCA-BAC-000001
TaxID: 543
| Rank: family
Biology & Ecology
Biology
Gram Statusgram-negative
Oxygen Tolerancefacultative anaerobe
Ecology
Primary Nichesgut
Reservoirenvironment, human
Clinical Profile
Pathobiont
yes
no
context dependent
unknown
Clinical Rolesopportunistic pathogen
Typical Specimenstool
Bloom Triggers
antibiotic exposure ·
hospitalization
Risk ContextsICU / critical care
Clinical Associations:
E2
E3 — Strong human clinical evidence
E2 — Moderate human evidence
E1 — Limited / preliminary
Enterobacteriaceae relative abundance was elevated approximately 10-fold in critically ill ICU patients compared to healthy controls during the first week of ICU admission, as measured by 16S rRNA sequencing of rectal swabs in a prospective cohort of 51 patients, representing the dominant compositional shift in ICU-associated gut dysbiosis.
PMID:
36894652
E2
E3 — Strong human clinical evidence
E2 — Moderate human evidence
E1 — Limited / preliminary
Progressive Enterobacteriaceae enrichment (≥2-fold increase between consecutive ICU time points) was independently associated with significantly increased odds of nosocomial infection (OR 6.8, 95% CI 1.7–25.3, p=0.01) compared to ICU patients without progressive enrichment, in a prospective cohort of 51 critically ill adults.
PMID:
36894652
E2
E3 — Strong human clinical evidence
E2 — Moderate human evidence
E1 — Limited / preliminary
Enterobacteriaceae relative abundance positively correlated with systemic inflammatory mediators (IL-8, IL-15, TNF-α, MIP-1α, IL-10) and immature neutrophils in ICU patients, indicating coupling of gut Enterobacteriaceae expansion to innate immune dysregulation during critical illness.
PMID:
36894652
Last reviewed: 2026-04-01
Evidence Timeline
Related Taxa
Shared Niche = same body site
Shared Risk = same vulnerable population
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