Alistipes indistinctus
Bacteria › Bacteroidota › Bacteroidia › Bacteroidales › Rikenellaceae › Alistipes
MCA-BAC-000050
TaxID: 626932
| Rank: species
Biology & Ecology
Biology
Gram Statusgram-negative
Oxygen Toleranceobligate anaerobe
Morphologybacillus (rod)
Ecology
Primary Nichesgut
Reservoirhuman
Clinical Profile
Pathobiont
yes
no
context dependent
unknown
Clinical Rolesprotective commensal
Typical Specimenstool
Risk ContextsNSCLC patients receiving PD-1/PD-L1 blockade
Clinical Associations:
E2
E3 — Strong human clinical evidence
E2 — Moderate human evidence
E1 — Limited / preliminary
Alistipes indistinctus was significantly enriched in NSCLC and RCC patients with longer progression-free survival (>3 months) vs. shorter PFS after PD-1/PD-L1 blockade, identified by shotgun metagenomics of pre-treatment stool (n=100) as one of several commensals overrepresented in responders.
PMID:
29097494
D002289
Carcinoma, Non-Small-Cell Lung
D000082082
Immune Checkpoint Inhibitors
H00014
Non-small cell lung cancer
H00021
Renal cell carcinoma
E1
E3 — Strong human clinical evidence
E2 — Moderate human evidence
E1 — Limited / preliminary
Oral gavage with Alistipes indistinctus reversed compromised PD-1 blockade efficacy in antibiotic-treated mice receiving NR-FMT-induced dysbiosis bearing MCA-205 sarcomas, restoring antitumor effects comparable to those of A. muciniphila supplementation (Fig. 4C).
PMID:
29097494
D000082082
Immune Checkpoint Inhibitors
D009369
Neoplasms
Last reviewed: 2026-04-03
Evidence Timeline
Related Taxa
Shared Niche = same body site
Shared Risk = same vulnerable population
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