Biology & Ecology
Biology
Gram Statusgram-negative
Oxygen Toleranceobligate anaerobe
Morphologybacillus (rod)
Ecology
Primary Nichesgut
Reservoirhuman
Clinical Profile
Pathobiont
yes
no
context dependent
unknown
Clinical Rolesbiomarker organism; opportunistic pathogen
Typical Specimenblood; stool
Risk Contextscancer patients; elderly patients; heart failure patients
Clinical Associations:
E2
E3 — Strong human clinical evidence
E2 — Moderate human evidence
E1 — Limited / preliminary
Prevotella copri is enriched in the gut microbiome of healthy controls compared to patients with non-small-cell lung cancer (NSCLC), as identified by LEfSe analysis of 16S rRNA stool sequencing from 96 NSCLC patients versus 139 healthy controls.
PMID:
33432149
E1
E3 — Strong human clinical evidence
E2 — Moderate human evidence
E1 — Limited / preliminary
Prevotella copri caused a clinically significant bloodstream infection (bacteremia) in a 90-year-old male patient with acute cardiac decompensation due to heart failure, representing the first reported case of BSI attributed to this organism; blood cultures grew P. copri as the sole pathogen and the patient recovered following treatment with metronidazole and piperacillin-tazobactam.
PMID:
31548871
E1
E3 — Strong human clinical evidence
E2 — Moderate human evidence
E1 — Limited / preliminary
Gut microbiota domination by Prevotella copri (6.1% relative abundance at species level; Prevotella genus 15.2% overall by 16S rRNA sequencing) was associated with subsequent P. copri bloodstream infection in the same patient, supporting a gut-to-blood translocation mechanism via intestinal barrier breach; the authors characterize P. copri as a pathobiont rather than a beneficial organism.
PMID:
31548871
Last reviewed: 2026-04-03
Evidence Timeline
Related Taxa
Shared Niche = same body site
Shared Risk = same vulnerable population
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